iOPTICS-GSO for identifying protein complexes from dynamic PPI networks
نویسندگان
چکیده
منابع مشابه
Identifying protein complexes and functional modules - from static PPI networks to dynamic PPI networks
Cellular processes are typically carried out by protein complexes and functional modules. Identifying them plays an important role for our attempt to reveal principles of cellular organizations and functions. In this article, we review computational algorithms for identifying protein complexes and/or functional modules from protein-protein interaction (PPI) networks. We first describe issues an...
متن کاملIdentifying protein complexes and functionalmodulesçfrom static PPI networks to dynamic PPI networks
Cellular processes are typically carried out by protein complexes and functional modules. Identifying them plays an important role for our attempt to reveal principles of cellular organizations and functions. In this article, we review computational algorithms for identifying protein complexes and/or functional modules from protein^protein interaction (PPI) networks. We first describe issues an...
متن کاملNeighbor Affinity-Based Core-Attachment Method to Detect Protein Complexes in Dynamic PPI Networks.
Protein complexes play significant roles in cellular processes. Identifying protein complexes from protein-protein interaction (PPI) networks is an effective strategy to understand biological processes and cellular functions. A number of methods have recently been proposed to detect protein complexes. However, most of methods predict protein complexes from static PPI networks, and usually overl...
متن کاملA Combination Method of Centrality Measures and Biological Properties to Improve Detection of Protein Complexes in Weighted PPI Networks
Introduction: In protein-protein interaction networks (PPINs), a complex is a group of proteins that allows a biological process to take place. The correct identification of complexes can help better understanding of the function of cells used for therapeutic purposes, such as drug discoveries. One of the common methods for identifying complexes in the PPINs is clustering, but this study aimed ...
متن کاملPredicting Protein Complexes from PPI Data: A Core-Attachment Approach
UNLABELLED Protein complexes play a critical role in many biological processes. Identifying the component proteins in a protein complex is an important step in understanding the complex as well as the related biological activities. This paper addresses the problem of predicting protein complexes from the protein-protein interaction (PPI) network of one species using a computational approach. Mo...
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2017
ISSN: 1755-8794
DOI: 10.1186/s12920-017-0314-x